Dexmedetomidine: More Than a Sedative and Analgesic
نویسندگان
چکیده
منابع مشابه
Dexmedetomidine: a novel sedative-analgesic agent.
Since the first report of clonidine, an alpha2-adrenoceptor agonist, the indications for this class of drugs have continued to expand. In December 1999, dexmedetomidine was approved as the most recent agent in this group and was introduced into clinical practice as a short-term sedative (<24 hours). Alpha2-adrenoceptor agonists have several beneficial actions during the perioperative period. Th...
متن کاملAnalgesic and sedative effects of intranasal dexmedetomidine in third molar surgery under local anaesthesia.
BACKGROUND Dexmedetomidine (DEX) is an alpha 2-adrenoreceptor agonist, which induces sedation and analgesia. This study aimed to determine whether intranasal DEX offered perioperative sedation and better postoperative analgesia. METHODS Patients having unilateral third molar surgery under local anaesthesia were recruited and allocated to receive either intranasal DEX 1 µg kg(-1) (Group D) or ...
متن کاملDexmedetomidine hydrochloride as a long-term sedative
Dexmedetomidine undoubtedly is a useful sedative in the intensive care setting because it has a minimal effect on the respiratory system. Dexmedetomidine infusions lasting more than 24 hours have not been approved since the first approval was acquired in the US in 1999. However, in 2008, dexmedetomidine infusions for prolonged use were approved in Colombia and in the Dominican Republic, and the...
متن کاملDexmedetomidine: Sedative and Neuroprotective Mechanisms of Action and New Developments
Dexmedetomidine, the D-enantiomer of medetomidine, is among the most potent sedative drugs known. It is also one of the best understood in terms of its molecular and cellular mechanisms. Its sedative (and probably its neuroprotective) effects are mediated by subtype A of the α2 adrenergic receptor, a G-protein-coupled receptor. Acting as an agonist at this receptor, dexmedetomidine causes numer...
متن کامل[Rectal dexmedetomidine in rats: evaluation of sedative and mucosal effects].
BACKGROUND AND OBJECTIVES In this study, we investigated the anesthetic and mucosal effects of the rectal application of dexmedetomidine to rats. METHODS Male Wistar albino rats weighing 250-300g were divided into four groups: Group S (n=8) was a sham group that served as a baseline for the normal basal values; Group C (n=8) consisted of rats that received the rectal application of saline alo...
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ژورنال
عنوان ژورنال: Acta Anaesthesiologica Taiwanica
سال: 2008
ISSN: 1875-4597
DOI: 10.1016/s1875-4597(09)60001-1